Seminar Title: Using New Approach Methods (NAMs) and multi omics to study metal toxicity mechanistically.
Seminar Abstract: Environmental factors drive neurodegeneration in various diseases like Parkinson’s (PD), Alzheimer’s disease (AD), and others. Manganese (Mn) overexposure is linked to development of a neurodegenerative disorder (Manganism) similar to PD. We have taken a bottom-up approach with untargeted high-resolution mass spectrometry proteomics and metabolomics using the brains of flies in a Manganism model. We have validated our findings using a cell culture and a rodent model of Mn toxicity. The multiomic analysis revealed that Mn- altered fatty acid oxidation and peroxisomes were enriched in the altered dataset, suggesting the potential importance of these less-studied organelles in Mn-toxicity. In summary, we demonstrated that the Peroxisomal biogenesis and reduced membrane contact sites between the peroxisome and mitochondria (PerMit) regulated Mn-induced neurotoxicity.
Zoom registration link: https://columbiacuimc.zoom.us/meeting/register/V2rIwi8mS-eZCoBAX0fbyA
If you would like to meet with Dr. Sarkar during the day of his visit, please reach out to Carolina Montes Garcia [email protected] to set up a 30-minute meeting.
